What is the adult dose of 1:1000 epinephrine?

• A. 0.3 mg
• B. 0.15 mg
• C. 0.5 mg
• D. 1.0 mg

Answer: (A)

For an adult experiencing anaphylaxis, the 1:1000 epinephrine dose given by intramuscular injection is 0.3 mg. This is the standard adult dose regardless of the route being intramuscular (the preferred route in BLS) because it delivers rapid onset with a dose appropriate for an adult’s body mass. The smaller 0.15 mg dose is used for pediatric patients or smaller adults, typically via auto-injectors designed for that weight range. In the prehospital setting, administer intramuscularly into the mid-outer thigh and repeat only if the protocol allows and symptoms persist. Intravenous use of 1:1000 epinephrine is not typical in BLS and carries greater risk; IV epinephrine for resuscitation uses a different concentration (1:10,000) and requires advanced care.